Searchable abstracts of presentations at key conferences in endocrinology

ea0041gp121 | Neuroendocrinology | ECE2016

Expression of dopamine (DA) D2 receptors (D2R) in corticotroph cells is responsible for the switch of hypothalamic regulation of ACTH secretion to DA in lactating rats

Nagy Gyorgy M. , Feher Palma , Bodnar Ibolya , Reid Luke , Toth Zsuzsanna E. , Vecsernyes Miklos , Toth Bela E.

: Hypothalamic regulation of pituitary adrenocorticotropic hormone (ACTH) secretion switches to dopamine (DA) with a parallel loss of DAerg control of alpha-melanocyte-stimulating hormone (α-MSH) release in lactating dams. It has been also shown that dephosphorylation/inactivation of tyrosine hydroxylase (TH) in terminals of DA neurons at the median eminence is required not only for suckling-induced PRL release but also for ACTH responses. The aim of the present study was...